Durban Poison – Sativa – Expect a major blow to the head from this super-potent strain. Durban Poison is one of the world’s more powerful strains. This strain hits with a strong, happy head high that’s great for creativity and daytime errands. Paranoia may be a possible side effect, along with dry mouth. Durban Poison is an effective treatment for depression and anxiety, as well as chronic pain, and it can also be helpful with nausea.